Assay Detail
Functional
CHEMBL1073224
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.99 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258320 | — | — | 1 | 9.00 |
| CHEMBL215484 | — | — | 1 | 8.70 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.66 |
| CHEMBL256247 | — | — | 1 | 8.52 |
| CHEMBL402847 | — | — | 1 | 8.40 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.35 |
| CHEMBL215692 | — | — | 1 | 8.30 |
| CHEMBL255539 | — | — | 1 | 8.22 |
| CHEMBL257422 | — | — | 1 | 8.22 |
| CHEMBL145251 | — | — | 1 | 8.19 |
| CHEMBL256795 | — | — | 1 | 8.15 |
| CHEMBL258319 | — | — | 1 | 7.96 |
| CHEMBL256797 | — | — | 1 | 7.92 |
| CHEMBL272090 | — | — | 1 | 7.85 |
| CHEMBL273018 | — | — | 1 | 7.85 |
| CHEMBL211920 | — | — | 1 | 7.80 |
| CHEMBL403091 | — | — | 1 | 7.75 |
| CHEMBL594198 | — | — | 1 | 7.50 |
| CHEMBL213259 | — | — | 1 | 7.33 |
| CHEMBL255758 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258320 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL215484 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL256247 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL402847 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL215692 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL255539 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL257422 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL145251 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL256795 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL258319 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL256797 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL272090 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL273018 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL211920 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL403091 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL594198 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL213259 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL255758 | — | IC50 | = | 7131.0 | nM | 5.15 |