Assay Detail
Functional
CHEMBL1768088
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.18 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3216087 | — | — | 1 | 8.70 |
| CHEMBL1765480 | — | — | 1 | 8.70 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.66 |
| CHEMBL3215856 | — | — | 1 | 8.52 |
| CHEMBL3216088 | — | — | 1 | 8.52 |
| CHEMBL3216971 | — | — | 1 | 8.40 |
| CHEMBL3216970 | — | — | 1 | 8.40 |
| CHEMBL3216747 | — | — | 1 | 8.40 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.35 |
| CHEMBL3216089 | — | — | 1 | 8.30 |
| CHEMBL1232057 | — | — | 1 | 8.11 |
| CHEMBL3216295 | — | — | 1 | 7.82 |
| CHEMBL3216513 | — | — | 1 | 7.77 |
| CHEMBL48217 | DAPI | — | 1 | 7.75 |
| CHEMBL3217178 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3216087 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1765480 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3215856 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3216088 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3216971 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3216970 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3216747 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3216089 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1232057 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3216295 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3216513 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL48217 | DAPI | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3217178 | — | IC50 | = | 484.0 | nM | 6.32 |