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Assay Detail

CHEMBL4222717

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against Plasmodium falciparum 3D7 asexual cultures grown under 5% haematocrit assessed as decrease in parasite DNA level by flow cytometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Evaluation of analogues of furan-amidines as inhibitors of NQO2.
Alnabulsi S, Hussein B, Santina E, Alsalahat I, Kadirvel M, Magwaza RN, Bryce RA, Schwalbe CH, Baldwin AG, Russo I, Stratford IJ, Freeman S.
Bioorg Med Chem Lett (2018) 28 : 1292 -1297
PubMed 29567345 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.25 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL24057 FURAMIDINE -1.0 1 9.30
CHEMBL4226422 1 6.51
CHEMBL4226269 1 6.11
CHEMBL4225437 1 6.01
CHEMBL3771399 1 5.82
CHEMBL4226437 1 5.28
CHEMBL4225974 1 4.72
CHEMBL4225163 1 -
CHEMBL4227500 1 -
CHEMBL4226084 1 -
CHEMBL4228545 1 -
CHEMBL4226216 1 -
CHEMBL4227197 1 -
CHEMBL4228043 1 -
CHEMBL165 RESVERATROL 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL24057 FURAMIDINE IC50 = 0.5 nM 9.30
CHEMBL4226422 IC50 = 310.0 nM 6.51
CHEMBL4226269 IC50 = 770.0 nM 6.11
CHEMBL4225437 IC50 = 970.0 nM 6.01
CHEMBL3771399 IC50 = 1500.0 nM 5.82
CHEMBL4226437 IC50 = 5300.0 nM 5.28
CHEMBL4225974 IC50 = 18900.0 nM 4.72
CHEMBL4225163 IC50 - -
CHEMBL4227500 IC50 - -
CHEMBL4226084 IC50 - -
CHEMBL4228545 IC50 - -
CHEMBL4226216 IC50 - -
CHEMBL4227197 IC50 - -
CHEMBL4228043 IC50 - -
CHEMBL165 RESVERATROL IC50 - -