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Assay Detail

CHEMBL944688

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against wild type Trypanosoma cruzi BS221 infected in mouse macrophage by reporter dye assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.
Rodenko B, van der Burg AM, Wanner MJ, Kaiser M, Brun R, Gould M, de Koning HP, Koomen GJ.
Antimicrob Agents Chemother (2007) 51 : 3796 -3802
PubMed 17698622 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.12 8.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL55 PENTAMIDINE 4.0 1 8.62
CHEMBL24057 FURAMIDINE -1.0 1 8.57
CHEMBL166 MELARSOPROL 3.0 1 8.39
CHEMBL515337 1 6.42
CHEMBL478498 1 6.41
CHEMBL515026 1 5.90
CHEMBL479007 1 5.84
CHEMBL518446 1 5.82
CHEMBL516902 1 5.29
CHEMBL518756 1 5.07
CHEMBL475085 1 5.03
CHEMBL478289 1 4.96
CHEMBL477280 1 4.78
CHEMBL478371 1 4.62
CHEMBL477084 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL55 PENTAMIDINE IC50 = 2.4 nM 8.62
CHEMBL24057 FURAMIDINE IC50 = 2.7 nM 8.57
CHEMBL166 MELARSOPROL IC50 = 4.1 nM 8.39
CHEMBL515337 IC50 = 380.0 nM 6.42
CHEMBL478498 IC50 = 390.0 nM 6.41
CHEMBL515026 IC50 = 1260.0 nM 5.90
CHEMBL479007 IC50 = 1460.0 nM 5.84
CHEMBL518446 IC50 = 1520.0 nM 5.82
CHEMBL516902 IC50 = 5150.0 nM 5.29
CHEMBL518756 IC50 = 8530.0 nM 5.07
CHEMBL475085 IC50 = 9280.0 nM 5.03
CHEMBL478289 IC50 = 10900.0 nM 4.96
CHEMBL477280 IC50 = 16600.0 nM 4.78
CHEMBL478371 IC50 = 24100.0 nM 4.62
CHEMBL477084 IC50 - -