Assay Detail
Functional
CHEMBL2422962
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 after 72 hrs by Alamar blue assay
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 65 | 6.15 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3707184 | — | — | 1 | 8.52 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.52 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.52 |
| CHEMBL2417998 | — | — | 1 | 8.52 |
| CHEMBL2418038 | — | — | 1 | 8.40 |
| CHEMBL2418029 | — | — | 1 | 8.30 |
| CHEMBL2418032 | — | — | 1 | 8.30 |
| CHEMBL3217252 | — | — | 1 | 8.30 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.22 |
| CHEMBL2418026 | — | — | 1 | 8.15 |
| CHEMBL2418035 | — | — | 1 | 8.00 |
| CHEMBL2418012 | — | — | 1 | 7.80 |
| CHEMBL2418015 | — | — | 1 | 7.77 |
| CHEMBL2418019 | — | — | 1 | 7.77 |
| CHEMBL2418034 | — | — | 1 | 7.72 |
| CHEMBL2418055 | — | — | 1 | 7.66 |
| CHEMBL2418018 | — | — | 1 | 7.62 |
| CHEMBL2418024 | — | — | 1 | 7.62 |
| CHEMBL2418010 | — | — | 1 | 7.55 |
| CHEMBL3216142 | — | — | 1 | 7.47 |
| CHEMBL2418051 | — | — | 1 | 7.04 |
| CHEMBL2418011 | — | — | 1 | 7.01 |
| CHEMBL3215927 | — | — | 1 | 6.96 |
| CHEMBL2418020 | — | — | 1 | 6.91 |
| CHEMBL3216825 | — | — | 1 | 6.74 |
| CHEMBL91187 | — | — | 1 | 6.32 |
| CHEMBL2418046 | — | — | 1 | 5.89 |
| CHEMBL2418052 | — | — | 1 | 5.87 |
| CHEMBL2418040 | — | — | 1 | 5.74 |
| CHEMBL2418041 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3707184 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2417998 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2418038 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2418029 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2418032 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3217252 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL166 | MELARSOPROL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2418026 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2418035 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2418012 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2418015 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2418019 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2418034 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2418055 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2418018 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2418024 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2418010 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3216142 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2418051 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL2418011 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL3215927 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2418020 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL3216825 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL91187 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL2418046 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL2418052 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL2418040 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL2418041 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2418049 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL2418042 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL2418045 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL2418048 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2418043 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL2418047 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL2418044 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL3217035 | — | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL2418050 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL90971 | — | IC50 | = | 9320.0 | nM | 5.03 |
| CHEMBL3216823 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL3217243 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL3217030 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL3217029 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3215690 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL3217240 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL3217251 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL3217033 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL3216144 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL3217038 | — | IC50 | = | 38700.0 | nM | 4.41 |