Assay Detail
Functional
CHEMBL887251
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Antiparasitic activity against Leishmania donovani
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.25 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231385 | — | — | 1 | 8.82 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.72 |
| CHEMBL231386 | — | — | 1 | 8.60 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.55 |
| CHEMBL397654 | — | — | 1 | 8.21 |
| CHEMBL231082 | — | — | 1 | 8.17 |
| CHEMBL231285 | — | — | 1 | 7.96 |
| CHEMBL228368 | — | — | 1 | 7.80 |
| CHEMBL228637 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231385 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL231386 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL397654 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL231082 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL231285 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL228368 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL228637 | — | IC50 | = | 35.0 | nM | 7.46 |