Assay Detail
Functional
CHEMBL4827164
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 measured after 72 hrs by alamar blue dye based fluorimetry analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
New antiparasitic flexible triaryl diamidines, their prodrugs and aza analogues: Synthesis, in vitro and in vivo biological evaluation, and molecular modelling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.67 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.66 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.35 |
| CHEMBL4862097 | — | — | 1 | 7.96 |
| CHEMBL4877093 | — | — | 1 | 7.82 |
| CHEMBL4867511 | — | — | 1 | 7.57 |
| CHEMBL4859955 | — | — | 1 | 7.46 |
| CHEMBL4877388 | — | — | 1 | 7.39 |
| CHEMBL4854237 | — | — | 1 | 7.14 |
| CHEMBL4849091 | — | — | 1 | 7.14 |
| CHEMBL4875142 | — | — | 1 | 6.98 |
| CHEMBL298415 | — | — | 1 | 6.42 |
| CHEMBL4865149 | — | — | 1 | 4.90 |
| CHEMBL4846149 | — | — | 1 | 4.84 |
| CHEMBL4867790 | — | — | 1 | 4.78 |
| CHEMBL4878609 | — | — | 1 | 4.73 |
| CHEMBL4850544 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4862097 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4877093 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4867511 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4859955 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4877388 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4854237 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4849091 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4875142 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL298415 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL4865149 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL4846149 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL4867790 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL4878609 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL4850544 | — | IC50 | = | 26100.0 | nM | 4.58 |