Assay Detail
Functional
CHEMBL887249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.17 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.55 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.37 |
| CHEMBL397654 | — | — | 1 | 8.21 |
| CHEMBL231082 | — | — | 1 | 7.55 |
| CHEMBL231285 | — | — | 1 | 6.94 |
| CHEMBL231385 | — | — | 1 | 6.51 |
| CHEMBL231386 | — | — | 1 | 6.45 |
| CHEMBL228368 | — | — | 1 | 6.24 |
| CHEMBL228637 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL397654 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL231082 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL231285 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL231385 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL231386 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL228368 | — | IC50 | = | 573.0 | nM | 6.24 |
| CHEMBL228637 | — | IC50 | = | 1900.0 | nM | 5.72 |