Assay Detail
Functional
CHEMBL5362064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiprotozoal activity against long slender blood stream form Trypanosoma brucei rhodesiense STIB900 assessed as parasite growth inhibition incubated for 70 hrs by resazurin based microplate fluorometer analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Investigation of the effect of structure modification of furamidine on the DNA minor groove binding and antiprotozoal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.98 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854793 | — | — | 1 | 8.70 |
| CHEMBL5438713 | — | — | 1 | 8.52 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.35 |
| CHEMBL4866022 | — | — | 1 | 8.22 |
| CHEMBL5440966 | — | — | 1 | 8.22 |
| CHEMBL5426298 | — | — | 1 | 8.22 |
| CHEMBL5414878 | — | — | 1 | 8.15 |
| CHEMBL4868476 | — | — | 1 | 7.92 |
| CHEMBL4853880 | — | — | 1 | 7.92 |
| CHEMBL4856398 | — | — | 1 | 7.82 |
| CHEMBL5398487 | — | — | 1 | 7.77 |
| CHEMBL1232046 | — | — | 1 | 7.57 |
| CHEMBL4851823 | — | — | 1 | 7.41 |
| CHEMBL62071 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854793 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5438713 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4866022 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5440966 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5426298 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5414878 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4868476 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4853880 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4856398 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5398487 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1232046 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4851823 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL62071 | — | IC50 | = | 122.0 | nM | 6.91 |