Compound Detail
CHEMBL5438713
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Basic Information
| ChEMBL ID | CHEMBL5438713 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RGOSCJSTDLGFRW-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
406.4
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 8.41 | 8.41 | 3.9 | 1 |
| L6 CHEMBL614793 | IC50 | 4.67 | 4.67 | 21500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei rhodesiense | IC50 | = | 3.0 | nM | 8.52 | Antiprotozoal activity against long slender blood stream form Trypanosoma brucei... | 36958267 |
| Plasmodium falciparum | IC50 | = | 3.9 | nM | 8.41 | Antiprotozoal activity against chloroquine resistant Plasmodium falciparum K1 in... | 36958267 |
| L6 | IC50 | = | 21500.0 | nM | 4.67 | Cytotoxicity against rat L6 cells assessed as reduction in cell viability incuba... | 36958267 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36958267 | 10.1016/j.ejmech.2023.115287 | AT rich DNA | 2 |
| 36958267 | 10.1016/j.ejmech.2023.115287 | Trypanosoma brucei rhodesiense | 2 |
| 36958267 | 10.1016/j.ejmech.2023.115287 | ADMET | 2 |
| 36958267 | 10.1016/j.ejmech.2023.115287 | Plasmodium falciparum | 1 |
| 36958267 | 10.1016/j.ejmech.2023.115287 | L6 | 1 |
Data from ChEMBL 36 via Core Engine