Assay Detail
Functional
CHEMBL5362065
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Antiprotozoal activity against chloroquine resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as parasite growth inhibition incubated for 48 hrs by [3H]-hypoxanthine incorporation assay based Betaplate liquid scintillation counter method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation of the effect of structure modification of furamidine on the DNA minor groove binding and antiprotozoal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.15 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854793 | — | — | 1 | 8.55 |
| CHEMBL5440966 | — | — | 1 | 8.55 |
| CHEMBL5414878 | — | — | 1 | 8.44 |
| CHEMBL5438713 | — | — | 1 | 8.41 |
| CHEMBL4868476 | — | — | 1 | 8.34 |
| CHEMBL4866022 | — | — | 1 | 8.24 |
| CHEMBL5398487 | — | — | 1 | 8.19 |
| CHEMBL4853880 | — | — | 1 | 8.14 |
| CHEMBL1232046 | — | — | 1 | 7.93 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 7.81 |
| CHEMBL62071 | — | — | 1 | 7.02 |
| CHEMBL5426298 | — | — | 1 | - |
| CHEMBL4851823 | — | — | 1 | - |
| CHEMBL4856398 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854793 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5440966 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5414878 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5438713 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4868476 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4866022 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5398487 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4853880 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL1232046 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL62071 | — | IC50 | = | 95.8 | nM | 7.02 |
| CHEMBL5426298 | — | IC50 | - | — | - | |
| CHEMBL4851823 | — | IC50 | - | — | - | |
| CHEMBL4856398 | — | IC50 | - | — | - |