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Target Snapshot

CHEMBL614004 Target Snapshot

A2780 · CELL-LINE · Homo sapiens

8,323Compounds
2,404Assays
67Approved Drugs
7,546.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats A2780 as ChEMBL target CHEMBL614004. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
A2780
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614004
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether A2780 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelA2780
UniProt AccessionN/A

A2780

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as A2780.

Review nameA2780
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

67
Approved
28
Phase III
35
Phase II
18
Phase I
Assay Mix

Activity Type Distribution

IC506,652.0
EC50894.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3094251 11.0 IC50 0.01 Preclinical
CHEMBL3094260 10.96 IC50 0.011 Preclinical
CHEMBL2321905 10.89 IC50 0.013 Preclinical
CHEMBL2324630 10.68 IC50 0.021 Preclinical
CHEMBL3094264 10.66 IC50 0.022 Preclinical
CHEMBL16498 10.65 IC50 0.0225 Clinical
CHEMBL3094255 10.6 IC50 0.025 Preclinical
CHEMBL3094223 10.52 IC50 0.03 Preclinical
CHEMBL2417793 10.52 IC50 0.03 Preclinical
CHEMBL1823147 10.52 IC50 0.03 Preclinical
Distribution

pChEMBL Value Distribution

1027
5.0
941
5.5
729
6.0
541
6.5
440
7.0
410
7.5
271
8.0
145
8.5
80
9.0
28
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACRITINIB
CHEMBL2035187
Approved 2022
ERDAFITINIB
CHEMBL3545376
Approved 2019
MIDOSTAURIN
CHEMBL608533
Approved 2017
PANOBINOSTAT
CHEMBL483254
Approved 2015
OLAPARIB
CHEMBL521686
Approved 2014
BELINOSTAT
CHEMBL408513
Approved 2014
AXITINIB
CHEMBL1289926
Approved 2012
PONATINIB
CHEMBL1171837
Approved 2012
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
VORINOSTAT
CHEMBL98
Approved 2006
PEMETREXED
CHEMBL225072
Approved 2004
CERIVASTATIN SODIUM
CHEMBL1200563
Approved 1997
GEMCITABINE
CHEMBL888
Approved 1996
TOPOTECAN
CHEMBL84
Approved 1996
DOCETAXEL ANHYDROUS
CHEMBL92
Approved 1995
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
PODOFILOX
CHEMBL61
Approved 1990
AMSACRINE
CHEMBL43
Approved 1987
MITOXANTRONE
CHEMBL58
Approved 1987
ETOPOSIDE
CHEMBL44657
Approved 1983
MITOMYCIN
CHEMBL105
Approved 1981
DAUNORUBICIN
CHEMBL178
Approved 1979
DOXORUBICIN
CHEMBL53463
Approved 1974
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
FLOXURIDINE
CHEMBL917
Approved 1970
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
DACTINOMYCIN
CHEMBL1554
Approved 1964
VINCRISTINE
CHEMBL90555
Approved 1963
COLCHICINE
CHEMBL107
Approved 1961
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

2,444
Total Assays
4,714
Tested Compounds
4
Assay Types
Functional — 2,392 assays, 4,714 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2,162 4,711 6.1
organism-based format 230 3 7.2
ADME — 45 assays, 90 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 45 90 6.1
Toxicity — 5 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 11 4.7
Unassigned — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine