Review anchor
A2780
CELL-LINE · Homo sapiens
As of 2026-09-13
Evidence Snapshot
A2780
CHEMBL614004
CELL-LINE
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats A2780 as ChEMBL target CHEMBL614004. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL614004
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why A2780 matters
A2780 is reviewed as A2780; the current evidence base includes 67 approved drugs, 8323 compounds, and 2404 assays, with lead potency reaching pChEMBL 11.0.
Protein context
A2780
A2780
Review this target as A2780.
Protein source · UniProt accession via ChEMBL component mappingDisease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 67 approved drugs, 8323 compounds, and 2404 assays for this target. The dominant activity type is IC50. CHEMBL3094251 is the current potency anchor at pChEMBL 11.0.
Use CHEMBL3094251 as the tractability anchor when discussing potency (pChEMBL 11.0).
Activity source · ChEMBL 36 via Core Engine
67 approved
pChEMBL 11.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why A2780 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
8323
Total Compounds
2404
Total Assays
67
Approved Drugs
IC50: 6652.0, EC50: 894.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL3094251
|
11.0 | IC50 | — |
|
|
No preferred name
CHEMBL3094260
|
11.0 | IC50 | — |
|
|
No preferred name
CHEMBL2321905
|
10.9 | IC50 | — |
|
|
No preferred name
CHEMBL2324630
|
10.7 | IC50 | — |
|
|
No preferred name
CHEMBL3094264
|
10.7 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
PACRITINIB
CHEMBL2035187
|
2022 |
|
|
ERDAFITINIB
CHEMBL3545376
|
2019 |
|
|
MIDOSTAURIN
CHEMBL608533
|
2017 |
|
|
PANOBINOSTAT
CHEMBL483254
|
2015 |
|
|
OLAPARIB
CHEMBL521686
|
2014 |
|
|
BELINOSTAT
CHEMBL408513
|
2014 |
|
|
AXITINIB
CHEMBL1289926
|
2012 |
|
|
PONATINIB
CHEMBL1171837
|
2012 |
|
|
TEMSIROLIMUS
CHEMBL1201182
|
2007 |
|
|
VORINOSTAT
CHEMBL98
|
2006 |
|
|
PEMETREXED
CHEMBL225072
|
2004 |
|
|
CERIVASTATIN SODIUM
CHEMBL1200563
|
1997 |
|
|
GEMCITABINE
CHEMBL888
|
1996 |
|
|
TOPOTECAN
CHEMBL84
|
1996 |
|
|
DOCETAXEL ANHYDROUS
CHEMBL92
|
1995 |
|
|
DOCETAXEL
CHEMBL3545252
|
1995 |
|
|
VINORELBINE
CHEMBL553025
|
1994 |
|
|
PACLITAXEL
CHEMBL428647
|
1992 |
|
|
PODOFILOX
CHEMBL61
|
1990 |
|
|
AMSACRINE
CHEMBL43
|
1987 |
|
|
MITOXANTRONE
CHEMBL58
|
1987 |
|
|
ETOPOSIDE
CHEMBL44657
|
1983 |
|
|
MITOMYCIN
CHEMBL105
|
1981 |
|
|
DAUNORUBICIN
CHEMBL178
|
1979 |
|
|
DOXORUBICIN
CHEMBL53463
|
1974 |
|
|
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
|
1974 |
|
|
FLOXURIDINE
CHEMBL917
|
1970 |
|
|
CYTARABINE
CHEMBL803
|
1969 |
|
|
VINBLASTINE
CHEMBL159
|
1965 |
|
|
DACTINOMYCIN
CHEMBL1554
|
1964 |
|
|
VINCRISTINE
CHEMBL90555
|
1963 |
|
|
COLCHICINE
CHEMBL107
|
1961 |
|
|
METHOTREXATE
CHEMBL34259
|
1953 |
Source Header