Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2399341

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 after 72 hrs by Alamar Blue assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei rhodesiense
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei rhodesiense (CHEMBL612348)
Type ORGANISM
Organism Trypanosoma brucei rhodesiense

Publication

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
Patrick DA, Ismail MA, Arafa RK, Wenzler T, Zhu X, Pandharkar T, Jones SK, Werbovetz KA, Brun R, Boykin DW, Tidwell RR.
J Med Chem (2013) 56 : 5473 -5494
PubMed 23795673 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 6.79 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL24057 FURAMIDINE -1.0 1 8.52
CHEMBL55 PENTAMIDINE 4.0 1 8.52
CHEMBL3215695 1 8.40
CHEMBL3217241 1 8.40
CHEMBL3217242 1 8.40
CHEMBL166 MELARSOPROL 3.0 1 8.40
CHEMBL3215928 1 8.30
CHEMBL3216357 1 8.22
CHEMBL2398505 1 7.77
CHEMBL3215932 1 7.72
CHEMBL3215693 1 7.70
CHEMBL2398506 1 7.66
CHEMBL3216356 1 7.54
CHEMBL3216348 1 7.51
CHEMBL3216824 1 7.36
CHEMBL3216141 1 7.33
CHEMBL3215706 1 7.28
CHEMBL3216349 1 7.26
CHEMBL3217031 1 7.17
CHEMBL3217255 1 7.01
CHEMBL3217037 1 6.96
CHEMBL3216816 1 6.85
CHEMBL3215933 1 6.75
CHEMBL2398504 1 6.28
CHEMBL3215925 1 6.27
CHEMBL3215934 1 6.21
CHEMBL3216821 1 6.20
CHEMBL3215694 1 6.16
CHEMBL3217254 1 6.09
CHEMBL3216815 1 5.93

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL24057 FURAMIDINE IC50 = 3.0 nM 8.52
CHEMBL55 PENTAMIDINE IC50 = 3.0 nM 8.52
CHEMBL3217241 IC50 = 4.0 nM 8.40
CHEMBL3217242 IC50 = 4.0 nM 8.40
CHEMBL166 MELARSOPROL IC50 = 4.0 nM 8.40
CHEMBL3215695 IC50 = 4.0 nM 8.40
CHEMBL3215928 IC50 = 5.0 nM 8.30
CHEMBL3216357 IC50 = 6.0 nM 8.22
CHEMBL2398505 IC50 = 17.0 nM 7.77
CHEMBL3215932 IC50 = 19.0 nM 7.72
CHEMBL3215693 IC50 = 20.0 nM 7.70
CHEMBL2398506 IC50 = 22.0 nM 7.66
CHEMBL3216356 IC50 = 29.0 nM 7.54
CHEMBL3216348 IC50 = 31.0 nM 7.51
CHEMBL3216824 IC50 = 44.0 nM 7.36
CHEMBL3216141 IC50 = 47.0 nM 7.33
CHEMBL3215706 IC50 = 52.0 nM 7.28
CHEMBL3216349 IC50 = 55.0 nM 7.26
CHEMBL3217031 IC50 = 68.0 nM 7.17
CHEMBL3217255 IC50 = 97.0 nM 7.01
CHEMBL3217037 IC50 = 109.0 nM 6.96
CHEMBL3216816 IC50 = 140.0 nM 6.85
CHEMBL3215933 IC50 = 178.0 nM 6.75
CHEMBL2398504 IC50 = 527.0 nM 6.28
CHEMBL3215925 IC50 = 533.0 nM 6.27
CHEMBL3215934 IC50 = 617.0 nM 6.21
CHEMBL3216821 IC50 = 635.0 nM 6.20
CHEMBL3215694 IC50 = 692.0 nM 6.16
CHEMBL3217254 IC50 = 809.0 nM 6.09
CHEMBL3216815 IC50 = 1170.0 nM 5.93
CHEMBL3215935 IC50 = 1600.0 nM 5.80
CHEMBL3217248 IC50 = 1940.0 nM 5.71
CHEMBL3215704 IC50 = 2550.0 nM 5.59
CHEMBL3215926 IC50 = 4440.0 nM 5.35
CHEMBL2398508 IC50 = 9840.0 nM 5.01
CHEMBL3215692 IC50 = 10900.0 nM 4.96
CHEMBL3215705 IC50 = 11300.0 nM 4.95
CHEMBL3216822 IC50 = 12300.0 nM 4.91
CHEMBL2398507 IC50 = 26300.0 nM 4.58
CHEMBL3217250 IC50 = 32400.0 nM 4.49