Assay Detail
Functional
CHEMBL916649
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 7.38 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376572 | — | — | 1 | 8.46 |
| CHEMBL227919 | — | — | 1 | 8.38 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.37 |
| CHEMBL227031 | — | — | 1 | 8.37 |
| CHEMBL388768 | — | — | 1 | 8.29 |
| CHEMBL227032 | — | — | 1 | 8.24 |
| CHEMBL441722 | — | — | 1 | 8.23 |
| CHEMBL228149 | — | — | 1 | 8.20 |
| CHEMBL228046 | — | — | 1 | 8.20 |
| CHEMBL227297 | — | — | 1 | 8.19 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.19 |
| CHEMBL227351 | — | — | 1 | 8.13 |
| CHEMBL228147 | — | — | 1 | 8.05 |
| CHEMBL227295 | — | — | 1 | 7.97 |
| CHEMBL227407 | — | — | 1 | 7.94 |
| CHEMBL388323 | — | — | 1 | 7.89 |
| CHEMBL227569 | — | — | 1 | 7.86 |
| CHEMBL227465 | — | — | 1 | 7.86 |
| CHEMBL227467 | — | — | 1 | 7.81 |
| CHEMBL228006 | — | — | 1 | 7.79 |
| CHEMBL389922 | — | — | 1 | 7.71 |
| CHEMBL388995 | — | — | 1 | 7.68 |
| CHEMBL388334 | — | — | 1 | 7.67 |
| CHEMBL228005 | — | — | 1 | 7.63 |
| CHEMBL389055 | — | — | 1 | 7.60 |
| CHEMBL390384 | — | — | 1 | 7.57 |
| CHEMBL388996 | — | — | 1 | 7.54 |
| CHEMBL227296 | — | — | 1 | 7.49 |
| CHEMBL227668 | — | — | 1 | 7.47 |
| CHEMBL388567 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376572 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL227919 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL227031 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL388768 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL227032 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL441722 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL228149 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL228046 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL227297 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL166 | MELARSOPROL | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL227351 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL228147 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL227295 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL227407 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL388323 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL227569 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL227465 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL227467 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL228006 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL389922 | — | IC50 | = | 19.4 | nM | 7.71 |
| CHEMBL388995 | — | IC50 | = | 20.9 | nM | 7.68 |
| CHEMBL388334 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL228005 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL389055 | — | IC50 | = | 25.1 | nM | 7.60 |
| CHEMBL390384 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL388996 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL227296 | — | IC50 | = | 32.4 | nM | 7.49 |
| CHEMBL227668 | — | IC50 | = | 34.2 | nM | 7.47 |
| CHEMBL388567 | — | IC50 | = | 44.8 | nM | 7.35 |
| CHEMBL226871 | — | IC50 | = | 46.3 | nM | 7.33 |
| CHEMBL226981 | — | IC50 | = | 51.2 | nM | 7.29 |
| CHEMBL226555 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL226816 | — | IC50 | = | 87.2 | nM | 7.06 |
| CHEMBL226815 | — | IC50 | = | 196.3 | nM | 6.71 |
| CHEMBL227613 | — | IC50 | = | 316.1 | nM | 6.50 |
| CHEMBL389221 | — | IC50 | = | 373.8 | nM | 6.43 |
| CHEMBL228218 | — | IC50 | = | 488.1 | nM | 6.31 |
| CHEMBL227667 | — | IC50 | = | 973.5 | nM | 6.01 |
| CHEMBL227240 | — | IC50 | = | 1120.8 | nM | 5.95 |
| CHEMBL227513 | — | IC50 | = | 1554.4 | nM | 5.81 |
| CHEMBL227700 | — | IC50 | = | 1628.3 | nM | 5.79 |
| CHEMBL269282 | — | IC50 | = | 1719.1 | nM | 5.76 |
| CHEMBL226767 | — | IC50 | = | 4983.4 | nM | 5.30 |
| CHEMBL390745 | — | IC50 | = | 18453.9 | nM | 4.73 |