Compound Detail
CHEMBL228006
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Basic Information
| ChEMBL ID | CHEMBL228006 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GTACVBLASLAFLL-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
335.4
MW (Da)
2.59
ALogP
5
HBA
4
HBD
135.0
PSA (Ų)
0.42
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.79
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 7.79 | 7.79 | 16.4 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 7.18 | 7.18 | 66.3 | 1 |
| L6 CHEMBL614793 | IC50 | 4.03 | 4.03 | 92600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei rhodesiense | IC50 | = | 16.4 | nM | 7.79 | Antitrypanosomal activity against Trypanosoma brucei rhodesiense | 17439202 |
| Plasmodium falciparum | IC50 | = | 66.3 | nM | 7.18 | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 | 17439202 |
| L6 | IC50 | = | 92600.0 | nM | 4.03 | Cytotoxicity against rat L6 cells | 17439202 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17439202 | 10.1021/jm0612867 | NON-PROTEIN TARGET | 2 |
| 17439202 | 10.1021/jm0612867 | Trypanosoma brucei rhodesiense | 1 |
| 17439202 | 10.1021/jm0612867 | Plasmodium falciparum | 1 |
| 17439202 | 10.1021/jm0612867 | L6 | 1 |
Data from ChEMBL 36 via Core Engine