Assay Detail
ADMET
CHEMBL916651
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Cytotoxicity against rat L6 cells
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 4.73 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.73 |
| CHEMBL226816 | — | — | 1 | 5.75 |
| CHEMBL388768 | — | — | 1 | 5.68 |
| CHEMBL226981 | — | — | 1 | 5.29 |
| CHEMBL388334 | — | — | 1 | 5.24 |
| CHEMBL228005 | — | — | 1 | 5.24 |
| CHEMBL227700 | — | — | 1 | 5.01 |
| CHEMBL227465 | — | — | 1 | 4.80 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 4.79 |
| CHEMBL227240 | — | — | 1 | 4.73 |
| CHEMBL269282 | — | — | 1 | 4.72 |
| CHEMBL389221 | — | — | 1 | 4.66 |
| CHEMBL227296 | — | — | 1 | 4.65 |
| CHEMBL228046 | — | — | 1 | 4.62 |
| CHEMBL390745 | — | — | 1 | 4.58 |
| CHEMBL227667 | — | — | 1 | 4.52 |
| CHEMBL376572 | — | — | 1 | 4.51 |
| CHEMBL227467 | — | — | 1 | 4.39 |
| CHEMBL228147 | — | — | 1 | 4.32 |
| CHEMBL227031 | — | — | 1 | 4.28 |
| CHEMBL226871 | — | — | 1 | 4.26 |
| CHEMBL227513 | — | — | 1 | 4.19 |
| CHEMBL388995 | — | — | 1 | 4.15 |
| CHEMBL227919 | — | — | 1 | 4.10 |
| CHEMBL228149 | — | — | 1 | 4.08 |
| CHEMBL388323 | — | — | 1 | 4.07 |
| CHEMBL227407 | — | — | 1 | 4.06 |
| CHEMBL228006 | — | — | 1 | 4.03 |
| CHEMBL227295 | — | — | 1 | - |
| CHEMBL388567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL226816 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL388768 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL226981 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL388334 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL228005 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL227700 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL227465 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL227240 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL269282 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL389221 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL227296 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL228046 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL390745 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL227667 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL376572 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL227467 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL228147 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL227031 | — | IC50 | = | 52800.0 | nM | 4.28 |
| CHEMBL226871 | — | IC50 | = | 55500.0 | nM | 4.26 |
| CHEMBL227513 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL388995 | — | IC50 | = | 71400.0 | nM | 4.15 |
| CHEMBL227919 | — | IC50 | = | 79900.0 | nM | 4.10 |
| CHEMBL228149 | — | IC50 | = | 82700.0 | nM | 4.08 |
| CHEMBL388323 | — | IC50 | = | 84800.0 | nM | 4.07 |
| CHEMBL227407 | — | IC50 | = | 87400.0 | nM | 4.06 |
| CHEMBL228006 | — | IC50 | = | 92600.0 | nM | 4.03 |
| CHEMBL227613 | — | IC50 | > | 185900.0 | nM | - |
| CHEMBL441722 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL227569 | — | IC50 | > | 212900.0 | nM | - |
| CHEMBL227668 | — | IC50 | = | 116200.0 | nM | - |
| CHEMBL227032 | — | IC50 | = | 191200.0 | nM | - |
| CHEMBL227297 | — | IC50 | = | 177000.0 | nM | - |
| CHEMBL228218 | — | IC50 | > | 187300.0 | nM | - |
| CHEMBL388996 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL226767 | — | IC50 | > | 180500.0 | nM | - |
| CHEMBL389055 | — | IC50 | = | 109400.0 | nM | - |
| CHEMBL389922 | — | IC50 | > | 205800.0 | nM | - |
| CHEMBL390384 | — | IC50 | > | 214800.0 | nM | - |
| CHEMBL226555 | — | IC50 | = | 177000.0 | nM | - |
| CHEMBL226815 | — | IC50 | > | 175800.0 | nM | - |
| CHEMBL227351 | — | IC50 | = | 124500.0 | nM | - |
| CHEMBL388567 | — | IC50 | > | 164400.0 | nM | - |
| CHEMBL227295 | — | IC50 | = | 122200.0 | nM | - |