Assay Detail
Functional
CHEMBL916650
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 7.74 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226981 | — | — | 1 | 8.68 |
| CHEMBL376572 | — | — | 1 | 8.60 |
| CHEMBL227569 | — | — | 1 | 8.59 |
| CHEMBL388995 | — | — | 1 | 8.46 |
| CHEMBL227297 | — | — | 1 | 8.46 |
| CHEMBL226816 | — | — | 1 | 8.39 |
| CHEMBL227295 | — | — | 1 | 8.22 |
| CHEMBL388323 | — | — | 1 | 8.21 |
| CHEMBL226815 | — | — | 1 | 8.18 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.17 |
| CHEMBL388334 | — | — | 1 | 8.15 |
| CHEMBL227467 | — | — | 1 | 8.10 |
| CHEMBL441722 | — | — | 1 | 8.05 |
| CHEMBL388996 | — | — | 1 | 8.04 |
| CHEMBL228218 | — | — | 1 | 7.97 |
| CHEMBL388567 | — | — | 1 | 7.94 |
| CHEMBL227031 | — | — | 1 | 7.94 |
| CHEMBL227407 | — | — | 1 | 7.85 |
| CHEMBL227465 | — | — | 1 | 7.83 |
| CHEMBL227296 | — | — | 1 | 7.83 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 7.81 |
| CHEMBL389055 | — | — | 1 | 7.79 |
| CHEMBL390384 | — | — | 1 | 7.76 |
| CHEMBL228149 | — | — | 1 | 7.73 |
| CHEMBL227351 | — | — | 1 | 7.72 |
| CHEMBL227668 | — | — | 1 | 7.71 |
| CHEMBL227919 | — | — | 1 | 7.68 |
| CHEMBL388768 | — | — | 1 | 7.65 |
| CHEMBL228147 | — | — | 1 | 7.59 |
| CHEMBL227032 | — | — | 1 | 7.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226981 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL376572 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL227569 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL388995 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL227297 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL226816 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL227295 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL388323 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL226815 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL388334 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL227467 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL441722 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL388996 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL228218 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL388567 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL227031 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL227407 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL227465 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL227296 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL389055 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL390384 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL228149 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL227351 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL227668 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL227919 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL388768 | — | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL228147 | — | IC50 | = | 25.9 | nM | 7.59 |
| CHEMBL227032 | — | IC50 | = | 29.7 | nM | 7.53 |
| CHEMBL389922 | — | IC50 | = | 30.4 | nM | 7.52 |
| CHEMBL226871 | — | IC50 | = | 30.6 | nM | 7.51 |
| CHEMBL227613 | — | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL226767 | — | IC50 | = | 43.1 | nM | 7.37 |
| CHEMBL227513 | — | IC50 | = | 51.2 | nM | 7.29 |
| CHEMBL228005 | — | IC50 | = | 55.5 | nM | 7.26 |
| CHEMBL228046 | — | IC50 | = | 57.8 | nM | 7.24 |
| CHEMBL228006 | — | IC50 | = | 66.3 | nM | 7.18 |
| CHEMBL227667 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL389221 | — | IC50 | = | 93.2 | nM | 7.03 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 103.5 | nM | 6.99 |
| CHEMBL226555 | — | IC50 | = | 104.5 | nM | 6.98 |
| CHEMBL390745 | — | IC50 | = | 227.2 | nM | 6.64 |
| CHEMBL227700 | — | IC50 | = | 334.3 | nM | 6.48 |
| CHEMBL227240 | — | IC50 | > | 3296.4 | nM | - |
| CHEMBL269282 | — | IC50 | > | 3296.4 | nM | - |