Assay Detail
Functional
CHEMBL3108259
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 assessed as growth inhibition after 70 hrs by Alamar blue assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.34 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217053 | — | — | 1 | 8.74 |
| CHEMBL3216615 | — | — | 1 | 8.57 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 8.52 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.52 |
| CHEMBL3216167 | — | — | 1 | 8.43 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.40 |
| CHEMBL3216850 | — | — | 1 | 8.23 |
| CHEMBL3217270 | — | — | 1 | 8.21 |
| CHEMBL3215723 | — | — | 1 | 8.14 |
| CHEMBL3217055 | — | — | 1 | 7.92 |
| CHEMBL3217057 | — | — | 1 | 7.87 |
| CHEMBL3216848 | — | — | 1 | 7.84 |
| CHEMBL3217049 | — | — | 1 | 7.80 |
| CHEMBL3105253 | — | — | 1 | 7.72 |
| CHEMBL3217052 | — | — | 1 | 7.62 |
| CHEMBL3217056 | — | — | 1 | 7.30 |
| CHEMBL3215961 | — | — | 1 | 7.28 |
| CHEMBL3216614 | — | — | 1 | 7.19 |
| CHEMBL3217274 | — | — | 1 | 6.74 |
| CHEMBL3217269 | — | — | 1 | 6.68 |
| CHEMBL3105271 | — | — | 1 | 6.31 |
| CHEMBL3215955 | — | — | 1 | 6.23 |
| CHEMBL3215722 | — | — | 1 | 6.22 |
| CHEMBL3216376 | — | — | 1 | 5.78 |
| CHEMBL3216170 | — | — | 1 | 5.47 |
| CHEMBL3217058 | — | — | 1 | 5.24 |
| CHEMBL3215956 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217053 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3216615 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3216167 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL166 | MELARSOPROL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3216850 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL3217270 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3215723 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL3217055 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL3217057 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL3216848 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL3217049 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3105253 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL3217052 | — | IC50 | = | 23.9 | nM | 7.62 |
| CHEMBL3217056 | — | IC50 | = | 50.5 | nM | 7.30 |
| CHEMBL3215961 | — | IC50 | = | 52.8 | nM | 7.28 |
| CHEMBL3216614 | — | IC50 | = | 64.3 | nM | 7.19 |
| CHEMBL3217274 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL3217269 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL3105271 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL3215955 | — | IC50 | = | 583.0 | nM | 6.23 |
| CHEMBL3215722 | — | IC50 | = | 596.0 | nM | 6.22 |
| CHEMBL3216376 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL3216170 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL3217058 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL3215956 | — | IC50 | = | 6120.0 | nM | 5.21 |