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Assay Detail

CHEMBL984623

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 after 72 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei rhodesiense
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei rhodesiense (CHEMBL612348)
Type ORGANISM
Organism Trypanosoma brucei rhodesiense

Publication

Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
Mathis AM, Bridges AS, Ismail MA, Kumar A, Francesconi I, Anbazhagan M, Hu Q, Tanious FA, Wenzler T, Saulter J, Wilson WD, Brun R, Boykin DW, Tidwell RR, Hall JE.
Antimicrob Agents Chemother (2007) 51 : 2801 -2810
PubMed 17517831 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.75 8.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL480523 1 8.77
CHEMBL424121 1 8.68
CHEMBL24057 FURAMIDINE -1.0 1 8.49
CHEMBL145251 1 8.19
CHEMBL448930 1 8.10
CHEMBL442905 1 8.01
CHEMBL358287 1 7.72
CHEMBL480120 1 7.50
CHEMBL520082 1 7.48
CHEMBL25999 1 7.22
CHEMBL23457 1 7.17
CHEMBL480121 1 6.83
CHEMBL58173 1 6.61

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL480523 IC50 = 1.7 nM 8.77
CHEMBL424121 IC50 = 2.1 nM 8.68
CHEMBL24057 FURAMIDINE IC50 = 3.2 nM 8.49
CHEMBL145251 IC50 = 6.5 nM 8.19
CHEMBL448930 IC50 = 8.0 nM 8.10
CHEMBL442905 IC50 = 9.7 nM 8.01
CHEMBL358287 IC50 = 19.0 nM 7.72
CHEMBL480120 IC50 = 32.0 nM 7.50
CHEMBL520082 IC50 = 33.0 nM 7.48
CHEMBL25999 IC50 = 60.0 nM 7.22
CHEMBL23457 IC50 = 68.0 nM 7.17
CHEMBL480121 IC50 = 147.0 nM 6.83
CHEMBL58173 IC50 = 245.0 nM 6.61