Assay Detail
Binding
CHEMBL1112959
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Inhibition of mouse p38alpha after 3 hrs by SPA method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of 2H-quinolizin-2-one based p38alpha MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.28 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219804 | — | — | 1 | 9.22 |
| CHEMBL1098525 | — | — | 1 | 8.82 |
| CHEMBL1096830 | — | — | 1 | 8.82 |
| CHEMBL94417 | — | — | 1 | 8.59 |
| CHEMBL1098822 | — | — | 1 | 8.28 |
| CHEMBL1098551 | — | — | 1 | 8.17 |
| CHEMBL1098524 | — | — | 1 | 8.15 |
| CHEMBL1098552 | — | — | 1 | 8.06 |
| CHEMBL1096192 | — | — | 1 | 7.89 |
| CHEMBL1098546 | — | — | 1 | 7.85 |
| CHEMBL1098554 | — | — | 1 | 7.83 |
| CHEMBL1098797 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219804 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1098525 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1096830 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL94417 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1098822 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1098551 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL1098524 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL1098552 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL1096192 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1098546 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1098554 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL1098797 | — | IC50 | = | 20.0 | nM | 7.70 |