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Assay Detail

CHEMBL1113200

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against recombinant HIV1 virus infected in human JC53BL cells after 3 days
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type JC53BL
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Spiropiperidine CCR5 antagonists.
Rotstein DM, Gabriel SD, Makra F, Filonova L, Gleason S, Brotherton-Pleiss C, Setti LQ, Trejo-Martin A, Lee EK, Sankuratri S, Ji C, Derosier A, Dioszegi M, Heilek G, Jekle A, Berry P, Weller P, Mau CI.
Bioorg Med Chem Lett (2009) 19 : 5401 -5406
PubMed 19674898 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 7.68 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1078714 1 8.70
CHEMBL1078713 1 8.52
CHEMBL1078712 1 8.52
CHEMBL1078711 1 8.40
CHEMBL1078936 1 8.40
CHEMBL1078231 1 8.22
CHEMBL1078809 1 8.10
CHEMBL1078937 1 7.92
CHEMBL1078723 1 7.85
CHEMBL1078014 1 7.62
CHEMBL1078753 1 7.54
CHEMBL1078013 1 7.51
CHEMBL1077912 1 7.34
CHEMBL1078710 1 7.28
CHEMBL1078335 1 7.26
CHEMBL1078434 1 7.08
CHEMBL1080794 1 6.90
CHEMBL1078659 1 6.43
CHEMBL1078015 1 6.39
CHEMBL1078141 1 -
CHEMBL1077779 1 -
CHEMBL1078648 1 -
CHEMBL1078647 1 -
CHEMBL1078072 1 -
CHEMBL1077989 1 -
CHEMBL1077988 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1078714 IC50 = 2.0 nM 8.70
CHEMBL1078713 IC50 = 3.0 nM 8.52
CHEMBL1078712 IC50 = 3.0 nM 8.52
CHEMBL1078711 IC50 = 4.0 nM 8.40
CHEMBL1078936 IC50 = 4.0 nM 8.40
CHEMBL1078231 IC50 = 6.0 nM 8.22
CHEMBL1078809 IC50 = 8.0 nM 8.10
CHEMBL1078937 IC50 = 12.0 nM 7.92
CHEMBL1078723 IC50 = 14.0 nM 7.85
CHEMBL1078014 IC50 = 24.0 nM 7.62
CHEMBL1078753 IC50 = 29.0 nM 7.54
CHEMBL1078013 IC50 = 31.0 nM 7.51
CHEMBL1077912 IC50 = 46.0 nM 7.34
CHEMBL1078710 IC50 = 52.0 nM 7.28
CHEMBL1078335 IC50 = 55.0 nM 7.26
CHEMBL1078434 IC50 = 84.0 nM 7.08
CHEMBL1080794 IC50 = 125.0 nM 6.90
CHEMBL1078659 IC50 = 375.0 nM 6.43
CHEMBL1078015 IC50 = 405.0 nM 6.39
CHEMBL1078141 IC50 > 625.0 nM -
CHEMBL1077779 IC50 < 1.2 nM -
CHEMBL1078648 IC50 > 625.0 nM -
CHEMBL1078647 IC50 > 625.0 nM -
CHEMBL1078072 IC50 > 625.0 nM -
CHEMBL1077989 IC50 > 625.0 nM -
CHEMBL1077988 IC50 > 625.0 nM -