Assay Detail
Functional
CHEMBL1113403
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Antagonist activity at AR in human MDA-kb2 cells co-transfected with MMTV-luc assessed as decrease in DHT-induced luciferase activity by reporter gene assay
13
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-kb2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.15 | 6.00 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL806 | FLUTAMIDE | 4.0 | 1 | 6.00 |
| CHEMBL42710 | EUGENOL | 0.5 | 3 | 4.72 |
| CHEMBL105912 | RASPBERRYKETONE | — | 3 | - |
| CHEMBL25894 | ZINGERONE | — | 3 | - |
| CHEMBL1090553 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL806 | FLUTAMIDE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL42710 | EUGENOL | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL42710 | EUGENOL | IC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL105912 | RASPBERRYKETONE | IC50 | = | 252000.0 | nM | - |
| CHEMBL25894 | ZINGERONE | IC50 | = | 153000.0 | nM | - |
| CHEMBL1090553 | — | IC50 | = | 420000.0 | nM | - |
| CHEMBL105912 | RASPBERRYKETONE | IC50 | = | 251188.64 | nM | - |
| CHEMBL25894 | ZINGERONE | IC50 | = | 151356.12 | nM | - |
| CHEMBL1090553 | — | IC50 | = | 416869.38 | nM | - |
| CHEMBL105912 | RASPBERRYKETONE | Activity | - | — | - | |
| CHEMBL42710 | EUGENOL | Activity | - | — | - | |
| CHEMBL25894 | ZINGERONE | Activity | - | — | - | |
| CHEMBL1090553 | — | Activity | - | — | - |