Assay Detail

CHEMBL1114087

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Functional

Antiviral activity against R5-tropic HIV Ba-L infected in human PBMC cells assessed as inhibition of viral replication

ChEMBL ↗

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Target

Human immunodeficiency virus (CHEMBL613758) ↗

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Human immunodeficiency virus (CHEMBL613758) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Human immunodeficiency virus

CHEMBL613758

Anchored from Assay target.

Protein identity Human immunodeficiency virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus
Cell Type	PBMC
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus (CHEMBL613758) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus

Publication

Spiropiperidine CCR5 antagonists.

Rotstein DM, Gabriel SD, Makra F, Filonova L, Gleason S, Brotherton-Pleiss C, Setti LQ, Trejo-Martin A, Lee EK, Sankuratri S, Ji C, Derosier A, Dioszegi M, Heilek G, Jekle A, Berry P, Weller P, Mau CI.
Bioorg Med Chem Lett (2009) 19 : 5401 -5406
PubMed 19674898 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.74	9.74

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1078231	—	—	1	9.74

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1078231	—	IC50	=	0.18	nM	9.74