Assay Detail
Binding
CHEMBL1114098
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant PDE4D by surface plasmon resonance assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Surface plasmon resonance-based detection of ladder-shaped polyethers by inhibition detection method.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 5.15 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1077126 | YESSOTOXIN | — | 1 | 6.00 |
| CHEMBL1077121 | DESULFATED YESSOTOXIN | — | 1 | 5.70 |
| CHEMBL1077122 | BREVETOXIN | — | 1 | 5.42 |
| CHEMBL500181 | — | — | 1 | 5.32 |
| CHEMBL1077119 | — | — | 1 | 4.96 |
| CHEMBL1086786 | — | — | 1 | 4.54 |
| CHEMBL1088484 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1077126 | YESSOTOXIN | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL1077121 | DESULFATED YESSOTOXIN | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL1077122 | BREVETOXIN | Kd | = | 3800.0 | nM | 5.42 |
| CHEMBL500181 | — | Kd | = | 4800.0 | nM | 5.32 |
| CHEMBL1077119 | — | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL1086786 | — | Kd | = | 29000.0 | nM | 4.54 |
| CHEMBL1088484 | — | Kd | = | 80000.0 | nM | 4.10 |