Compound Detail
CHEMBL1088484
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Basic Information
| ChEMBL ID | CHEMBL1088484 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MONANRYKMPEKTM-FNAHDJPLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
372.5
MW (Da)
2.69
ALogP
5
HBA
2
HBD
68.2
PSA (Ų)
0.66
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 4.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | Kd | 4.1 | 4.1 | 80000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D | Kd | = | 80000.0 | nM | 4.1 | Binding affinity to recombinant PDE4D by surface plasmon resonance assay | 19361990 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19361990 | 10.1016/j.bmcl.2009.03.103 | Unchecked | 1 |
| 19361990 | 10.1016/j.bmcl.2009.03.103 | 3',5'-cyclic-AMP phosphodiesterase 4D | 1 |
Data from ChEMBL 36 via Core Engine