Assay Detail
Binding
CHEMBL1114100
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of radiolabeled estrogen from estrogen receptor alpha by scintillation counting
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification and structure-activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 7.92 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088485 | — | — | 1 | 8.96 |
| CHEMBL1086775 | — | — | 1 | 8.92 |
| CHEMBL1083178 | — | — | 1 | 8.92 |
| CHEMBL1087811 | — | — | 1 | 8.80 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 8.74 |
| CHEMBL1087545 | — | — | 1 | 8.66 |
| CHEMBL1086774 | — | — | 1 | 8.62 |
| CHEMBL1086776 | — | — | 1 | 8.60 |
| CHEMBL1087557 | — | — | 1 | 8.58 |
| CHEMBL1083186 | — | — | 1 | 8.48 |
| CHEMBL1082224 | — | — | 1 | 8.48 |
| CHEMBL1088631 | — | — | 1 | 8.47 |
| CHEMBL1087418 | — | — | 1 | 8.40 |
| CHEMBL1087426 | — | — | 1 | 8.38 |
| CHEMBL1088344 | — | — | 1 | 8.38 |
| CHEMBL1087297 | — | — | 1 | 8.35 |
| CHEMBL1083194 | — | — | 1 | 8.32 |
| CHEMBL1085161 | — | — | 1 | 8.32 |
| CHEMBL1084128 | — | — | 1 | 8.30 |
| CHEMBL1088629 | — | — | 1 | 8.30 |
| CHEMBL1082528 | — | — | 1 | 8.30 |
| CHEMBL1085669 | — | — | 1 | 8.27 |
| CHEMBL1085899 | — | — | 1 | 8.25 |
| CHEMBL1087298 | — | — | 1 | 8.24 |
| CHEMBL1088343 | — | — | 1 | 8.24 |
| CHEMBL1088337 | — | — | 1 | 8.21 |
| CHEMBL1082864 | — | — | 1 | 8.20 |
| CHEMBL1086652 | — | — | 1 | 8.20 |
| CHEMBL1084120 | — | — | 1 | 8.15 |
| CHEMBL1084922 | — | — | 1 | 8.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088485 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1086775 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1083178 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1087811 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1087545 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1086774 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1086776 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1087557 | — | IC50 | = | 2.63 | nM | 8.58 |
| CHEMBL1083186 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1082224 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1088631 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL1087418 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1088344 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1087426 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1087297 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1083194 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1085161 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1084128 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1088629 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1082528 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1085669 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1085899 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL1087298 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1088343 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1088337 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL1086652 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL1082864 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL1084120 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1084922 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1084129 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1088483 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1087812 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1082539 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1085668 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1087919 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL1084127 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1087419 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1086389 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1087546 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1086644 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1087682 | — | IC50 | = | 40.97 | nM | 7.39 |
| CHEMBL1087547 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1085429 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1087288 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1087289 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1083179 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL1083187 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1087040 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1082529 | — | IC50 | = | 180.0 | nM | 6.75 |