Estrogen receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Estrogen receptor shows approved-linked disease relevance led by breast cancer. 5 more disease programs remain visible in the same review block. 11 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P03372. Start with breast cancer, then reuse UniProt P03372 as the stable protein anchor across project notes and exports.
Start with breast cancer, then reuse UniProt P03372 as the stable protein anchor across project notes and exports.
Estrogen receptor shows approved-linked disease relevance led by breast cancer. 5 more disease programs remain visible in the same review block. 11 linked drugs remain visible in the same block.
Start review with breast cancer because it currently carries approved-linked support. Linked drugs include AMCENESTRANT, BRILANESTRANT, CAMIZESTRANT, ELACESTRANT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyEstrogen receptor
Review this target as Estrogen receptor, mapped to UniProt P03372. Sequence length is 595 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Estrogen receptor as ChEMBL target CHEMBL206, mapped to UniProt P03372. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Estrogen receptor is the right protein anchor across sources, using UniProt P03372 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why breast cancer is currently framed as approved-linked support. It currently carries 11 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Estrogen receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P03372 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Estrogen receptor |
| UniProt Accession | P03372 |
| Component Type | Protein |
| Sequence Length | 595 aa |
Estrogen receptor
Review this target as Estrogen receptor, mapped to UniProt P03372. Sequence length is 595 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Estrogen receptor shows approved-linked disease relevance led by breast cancer. 5 more disease programs remain visible in the same review block.
Start review with breast cancer because it currently carries approved-linked support. Linked drugs include AMCENESTRANT, BRILANESTRANT, CAMIZESTRANT, ELACESTRANT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL135 | 11.0 | EC50 | 0.01 | Approved |
| CHEMBL4591338 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL5177342 | 10.85 | EC50 | 0.014 | Preclinical |
| CHEMBL149791 | 10.82 | EC50 | 0.015 | Preclinical |
| CHEMBL4439408 | 10.68 | IC50 | 0.021 | Preclinical |
| CHEMBL592868 | 10.55 | EC50 | 0.028 | Clinical |
| CHEMBL5787193 | 10.54 | EC50 | 0.029 | Preclinical |
| CHEMBL81 | 10.52 | Ki | 0.03 | Approved |
| CHEMBL4447340 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL4441471 | 10.52 | IC50 | 0.03 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 869 | 1,569 | 7.8 |
| single protein format | 610 | 2,423 | 7.0 |
| assay format | 66 | 357 | 7.2 |
| organism-based format | 13 | 577 | 8.0 |
| mitochondrion format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 165 | 349 | 6.9 |
| assay format | 31 | 65 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 25 | 27 | 6.8 |
| single protein format | 6 | 14 | 5.1 |