Compound Detail
CHEMBL592868
ESTROGEN 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL592868 |
| Name | ESTROGEN |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | GJUHUIXJLZINMA-MJCUULBUSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
1
Known Names
5
Indications
Molecular Properties
310.4
MW (Da)
4.00
ALogP
2
HBA
2
HBD
40.5
PSA (Ų)
0.71
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Unknown |
Indications
Alzheimer Disease Breast Neoplasms Heart Diseases Memory Disorders Arthralgia
Activity Summary
EC50 1 meas. best 10.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Estrogen receptor CHEMBL206 | EC50 | 10.55 | 10.55 | 0.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Estrogen receptor | EC50 | = | 0.028 | nM | 10.55 | Estrogenic activity at ERalpha in human Ishikawa cells assessed as stimulation o... | 20031420 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22194678 | 10.1371/journal.pcbi.1002310 | Hepatotoxicity | 14 |
| 1249807 | 10.1021/jm00224a014 | Rattus norvegicus | 3 |
| 7853335 | 10.1021/jm00003a005 | Estrogen receptor | 2 |
| 20031420 | 10.1016/j.bmc.2009.11.046 | Estrogen receptor | 1 |
| 24900787 | 10.1021/ml400397k | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine