Assay Detail
Functional
CHEMBL1114101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17-beta-estradiol-induced alkaline phosphatase activity after 3 days by chemiluminescence assay
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Ishikawa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and structure-activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 6.97 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088485 | — | — | 1 | 9.70 |
| CHEMBL1087419 | — | — | 1 | 8.10 |
| CHEMBL1086775 | — | — | 1 | 8.00 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 7.62 |
| CHEMBL1082864 | — | — | 1 | 7.59 |
| CHEMBL1086652 | — | — | 1 | 7.59 |
| CHEMBL1088631 | — | — | 1 | 7.50 |
| CHEMBL1085899 | — | — | 1 | 7.46 |
| CHEMBL1087545 | — | — | 1 | 7.39 |
| CHEMBL1087811 | — | — | 1 | 7.37 |
| CHEMBL1083186 | — | — | 1 | 7.21 |
| CHEMBL1087297 | — | — | 1 | 7.17 |
| CHEMBL1087298 | — | — | 1 | 7.12 |
| CHEMBL1088343 | — | — | 1 | 7.12 |
| CHEMBL1082224 | — | — | 1 | 7.09 |
| CHEMBL1083178 | — | — | 1 | 7.06 |
| CHEMBL1084922 | — | — | 1 | 7.05 |
| CHEMBL1084128 | — | — | 1 | 6.95 |
| CHEMBL1088629 | — | — | 1 | 6.95 |
| CHEMBL1086644 | — | — | 1 | 6.92 |
| CHEMBL1084120 | — | — | 1 | 6.91 |
| CHEMBL1086774 | — | — | 1 | 6.89 |
| CHEMBL1084129 | — | — | 1 | 6.88 |
| CHEMBL1086389 | — | — | 1 | 6.87 |
| CHEMBL1087418 | — | — | 1 | 6.84 |
| CHEMBL1087426 | — | — | 1 | 6.82 |
| CHEMBL1088344 | — | — | 1 | 6.82 |
| CHEMBL1087919 | — | — | 1 | 6.80 |
| CHEMBL1082528 | — | — | 1 | 6.79 |
| CHEMBL1086776 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088485 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1087419 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1086775 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1082864 | — | IC50 | = | 25.9 | nM | 7.59 |
| CHEMBL1086652 | — | IC50 | = | 25.9 | nM | 7.59 |
| CHEMBL1088631 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1085899 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1087545 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1087811 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1083186 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1087297 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1087298 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1088343 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1082224 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1083178 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1084922 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1084128 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1088629 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1086644 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL1084120 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL1086774 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL1084129 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL1086389 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL1087418 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL1087426 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1088344 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1087919 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL1082528 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL1086776 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL1084127 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL1087289 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL1088483 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL1085669 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL1082539 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL1085668 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL1087546 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1087547 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1085429 | — | IC50 | = | 1736.0 | nM | 5.76 |
| CHEMBL1087288 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL1082529 | — | IC50 | = | 8990.0 | nM | 5.05 |
| CHEMBL83 | TAMOXIFEN | IC50 | - | — | - | |
| CHEMBL1087290 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1086388 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1083805 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1083497 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1087041 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1087040 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1083188 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1083187 | — | IC50 | > | 10000.0 | nM | - |