Assay Detail
Functional
CHEMBL1114562
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Antiproliferative activity against human MCF7/ADR cells after 72 hrs by sulforhodamine B assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.53 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096926 | — | — | 1 | 6.70 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 4.35 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096926 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 44900.0 | nM | 4.35 |
| CHEMBL90555 | VINCRISTINE | IC50 | - | — | - |