Assay Detail
Functional
CHEMBL1114563
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SGC7901 cells after 72 hrs by sulforhodamine B assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SGC-7901 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 4.85 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096926 | — | — | 1 | 7.52 |
| CHEMBL1095909 | — | — | 1 | 7.40 |
| CHEMBL1097928 | — | — | 1 | 6.77 |
| CHEMBL1097930 | — | — | 1 | 6.20 |
| CHEMBL1094270 | — | — | 1 | 6.08 |
| CHEMBL1095908 | — | — | 1 | 5.13 |
| CHEMBL1098955 | — | — | 1 | 4.68 |
| CHEMBL1095906 | — | — | 1 | 4.67 |
| CHEMBL1098924 | — | — | 1 | 4.63 |
| CHEMBL1098923 | — | — | 1 | 4.62 |
| CHEMBL1094607 | — | — | 1 | 4.58 |
| CHEMBL215065 | — | — | 1 | 4.49 |
| CHEMBL1098604 | — | — | 1 | 4.49 |
| CHEMBL1096925 | — | — | 1 | 4.27 |
| CHEMBL1098927 | — | — | 1 | 4.21 |
| CHEMBL1098954 | — | — | 1 | 4.16 |
| CHEMBL1099291 | — | — | 1 | 4.14 |
| CHEMBL1098953 | — | — | 1 | 4.11 |
| CHEMBL1097946 | — | — | 1 | 4.10 |
| CHEMBL1098603 | — | — | 1 | 4.10 |
| CHEMBL1097257 | — | — | 1 | 4.06 |
| CHEMBL1097947 | — | — | 1 | 4.05 |
| CHEMBL1095271 | — | — | 1 | 4.03 |
| CHEMBL1094271 | — | — | 1 | 4.00 |
| CHEMBL1098290 | — | — | 1 | - |
| CHEMBL1098601 | — | — | 1 | - |
| CHEMBL1098602 | — | — | 1 | - |
| CHEMBL1098952 | — | — | 1 | - |
| CHEMBL1095907 | — | — | 1 | - |
| CHEMBL1094608 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096926 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1095909 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1097928 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1097930 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1094270 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1095908 | — | IC50 | = | 7360.0 | nM | 5.13 |
| CHEMBL1098955 | — | IC50 | = | 20690.0 | nM | 4.68 |
| CHEMBL1095906 | — | IC50 | = | 21417.0 | nM | 4.67 |
| CHEMBL1098924 | — | IC50 | = | 23480.0 | nM | 4.63 |
| CHEMBL1098923 | — | IC50 | = | 23690.0 | nM | 4.62 |
| CHEMBL1094607 | — | IC50 | = | 26480.0 | nM | 4.58 |
| CHEMBL215065 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL1098604 | — | IC50 | = | 32270.0 | nM | 4.49 |
| CHEMBL1096925 | — | IC50 | = | 53680.0 | nM | 4.27 |
| CHEMBL1098927 | — | IC50 | = | 61290.0 | nM | 4.21 |
| CHEMBL1098954 | — | IC50 | = | 69390.0 | nM | 4.16 |
| CHEMBL1099291 | — | IC50 | = | 72190.0 | nM | 4.14 |
| CHEMBL1098953 | — | IC50 | = | 78590.0 | nM | 4.11 |
| CHEMBL1097946 | — | IC50 | = | 79410.0 | nM | 4.10 |
| CHEMBL1098603 | — | IC50 | = | 79870.0 | nM | 4.10 |
| CHEMBL1097257 | — | IC50 | = | 87600.0 | nM | 4.06 |
| CHEMBL1097947 | — | IC50 | = | 89570.0 | nM | 4.05 |
| CHEMBL1095271 | — | IC50 | = | 92900.0 | nM | 4.03 |
| CHEMBL1094271 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1094910 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1099252 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098270 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1097929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1097927 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098925 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1094608 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1095907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098952 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098602 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098601 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098290 | — | IC50 | > | 100000.0 | nM | - |