Assay Detail
Functional
CHEMBL1114569
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Antiproliferative activity against human HT-29 cells after 72 hrs by sulforhodamine B assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 4.84 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096926 | — | — | 1 | 7.70 |
| CHEMBL1095909 | — | — | 1 | 7.40 |
| CHEMBL1094270 | — | — | 1 | 6.60 |
| CHEMBL1097930 | — | — | 1 | 6.39 |
| CHEMBL1097928 | — | — | 1 | 6.35 |
| CHEMBL1095908 | — | — | 1 | 4.94 |
| CHEMBL1097929 | — | — | 1 | 4.89 |
| CHEMBL1095906 | — | — | 1 | 4.87 |
| CHEMBL1098923 | — | — | 1 | 4.81 |
| CHEMBL1094607 | — | — | 1 | 4.77 |
| CHEMBL1098955 | — | — | 1 | 4.74 |
| CHEMBL1098924 | — | — | 1 | 4.68 |
| CHEMBL1098604 | — | — | 1 | 4.54 |
| CHEMBL1094910 | — | — | 1 | 4.37 |
| CHEMBL1098927 | — | — | 1 | 4.32 |
| CHEMBL1098954 | — | — | 1 | 4.26 |
| CHEMBL1095907 | — | — | 1 | 4.24 |
| CHEMBL1098953 | — | — | 1 | 4.23 |
| CHEMBL1099291 | — | — | 1 | 4.20 |
| CHEMBL1098603 | — | — | 1 | 4.13 |
| CHEMBL1096925 | — | — | 1 | 4.12 |
| CHEMBL1097947 | — | — | 1 | 4.08 |
| CHEMBL1097946 | — | — | 1 | 4.08 |
| CHEMBL1095271 | — | — | 1 | 4.07 |
| CHEMBL1097257 | — | — | 1 | 4.01 |
| CHEMBL1098270 | — | — | 1 | 4.00 |
| CHEMBL215065 | — | — | 1 | 4.00 |
| CHEMBL1094271 | — | — | 1 | - |
| CHEMBL1094608 | — | — | 1 | - |
| CHEMBL1098290 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096926 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1095909 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1094270 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1097930 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1097928 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1095908 | — | IC50 | = | 11520.0 | nM | 4.94 |
| CHEMBL1097929 | — | IC50 | = | 12830.0 | nM | 4.89 |
| CHEMBL1095906 | — | IC50 | = | 13380.0 | nM | 4.87 |
| CHEMBL1098923 | — | IC50 | = | 15550.0 | nM | 4.81 |
| CHEMBL1094607 | — | IC50 | = | 16990.0 | nM | 4.77 |
| CHEMBL1098955 | — | IC50 | = | 18110.0 | nM | 4.74 |
| CHEMBL1098924 | — | IC50 | = | 20680.0 | nM | 4.68 |
| CHEMBL1098604 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL1094910 | — | IC50 | = | 42250.0 | nM | 4.37 |
| CHEMBL1098927 | — | IC50 | = | 48100.0 | nM | 4.32 |
| CHEMBL1098954 | — | IC50 | = | 54350.0 | nM | 4.26 |
| CHEMBL1095907 | — | IC50 | = | 57500.0 | nM | 4.24 |
| CHEMBL1098953 | — | IC50 | = | 58940.0 | nM | 4.23 |
| CHEMBL1099291 | — | IC50 | = | 63880.0 | nM | 4.20 |
| CHEMBL1098603 | — | IC50 | = | 74710.0 | nM | 4.13 |
| CHEMBL1096925 | — | IC50 | = | 75650.0 | nM | 4.12 |
| CHEMBL1097947 | — | IC50 | = | 82290.0 | nM | 4.08 |
| CHEMBL1097946 | — | IC50 | = | 82350.0 | nM | 4.08 |
| CHEMBL1095271 | — | IC50 | = | 85530.0 | nM | 4.07 |
| CHEMBL1097257 | — | IC50 | = | 97180.0 | nM | 4.01 |
| CHEMBL1098270 | — | IC50 | = | 99160.0 | nM | 4.00 |
| CHEMBL215065 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1099252 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1097927 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098925 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098952 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098602 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098601 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1098290 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1094608 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1094271 | — | IC50 | > | 100000.0 | nM | - |