Assay Detail
Functional
CHEMBL1114586
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562/A02 cells after 72 hrs by sulforhodamine B assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562/A02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.92 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096926 | — | — | 1 | 7.22 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 4.62 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096926 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 23810.0 | nM | 4.62 |
| CHEMBL90555 | VINCRISTINE | IC50 | - | — | - |