Assay Detail
Binding
CHEMBL1114713
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Inhibition of rabbit muscle glycogen phosphorylase inactive form b
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glycogen phosphorylase, muscle form (CHEMBL4696) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.79 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1096135 | — | — | 1 | 5.21 |
| CHEMBL1096136 | — | — | 1 | 5.11 |
| CHEMBL3351143 | — | — | 1 | 4.50 |
| CHEMBL1095543 | — | — | 1 | 4.33 |
| CHEMBL1095230 | — | — | 1 | - |
| CHEMBL1095544 | — | — | 1 | - |
| CHEMBL1095545 | — | — | 1 | - |
| CHEMBL1094537 | — | — | 1 | - |
| CHEMBL423707 | — | — | 1 | - |
| CHEMBL1614854 | beta-D-Glucose | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1096135 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL1096136 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL3351143 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL1095543 | — | Ki | = | 46420.0 | nM | 4.33 |
| CHEMBL1095230 | — | Ki | = | 3460000.0 | nM | - |
| CHEMBL1095544 | — | Ki | = | 4010000.0 | nM | - |
| CHEMBL1095545 | — | Ki | = | 3670000.0 | nM | - |
| CHEMBL1094537 | — | Ki | = | 6550000.0 | nM | - |
| CHEMBL423707 | — | Ki | = | 1700000.0 | nM | - |
| CHEMBL1614854 | beta-D-Glucose | Ki | = | 7400000.0 | nM | - |