Assay Detail
Binding
CHEMBL1114776
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Inhibition of Plasmodium falciparum plasmepsin-2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.56 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112598 | — | — | 1 | 9.30 |
| CHEMBL163104 | — | — | 1 | 6.92 |
| CHEMBL104538 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112598 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL163104 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL104538 | — | Ki | = | 357.0 | nM | 6.45 |