Assay Detail
Binding
CHEMBL1114779
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Displacement of [3H]Ro5-4864 from TSPO in rat kidney mitochondrial membrane
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Kidney |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.45 | 7.64 |
| IC50 | 3 | 7.31 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286346 | RO-54864 | — | 1 | 7.64 |
| CHEMBL1097176 | — | — | 2 | 7.42 |
| CHEMBL1099012 | — | — | 2 | 7.42 |
| CHEMBL1097503 | — | — | 2 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286346 | RO-54864 | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1097176 | — | Ki | = | 37.9 | nM | 7.42 |
| CHEMBL1099012 | — | Ki | = | 37.6 | nM | 7.42 |
| CHEMBL1099012 | — | IC50 | = | 42.2 | nM | 7.38 |
| CHEMBL1097176 | — | IC50 | = | 45.6 | nM | 7.34 |
| CHEMBL1097503 | — | Ki | = | 49.5 | nM | 7.30 |
| CHEMBL1097503 | — | IC50 | = | 59.7 | nM | 7.22 |