Assay Detail
Binding
CHEMBL1116964
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Inhibition of human recombinant COMT by microplate screening assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.26 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091204 | — | — | 1 | 8.96 |
| CHEMBL1089630 | — | — | 1 | 8.89 |
| CHEMBL1091983 | — | — | 1 | 8.80 |
| CHEMBL1089504 | — | — | 1 | 8.66 |
| CHEMBL1091982 | — | — | 1 | 8.22 |
| CHEMBL1089505 | — | — | 1 | 8.04 |
| CHEMBL1089536 | — | — | 1 | 7.99 |
| CHEMBL1089539 | — | — | 1 | 7.97 |
| CHEMBL1091981 | — | — | 1 | 7.78 |
| CHEMBL1089538 | — | — | 1 | 7.77 |
| CHEMBL1089537 | — | — | 1 | 7.77 |
| CHEMBL1089503 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091204 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1089630 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL1091983 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL1089504 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL1091982 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL1089505 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL1089536 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL1089539 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL1091981 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL1089538 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL1089537 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL1089503 | — | Ki | < | 1.0 | nM | - |