Assay Detail
Functional
CHEMBL1117045
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Antiproliferative activity against human LNCAP cells after 3 days by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 2-ureidophenyltriazines bearing bridged morpholines as potent and selective ATP-competitive mTOR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.12 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088973 | — | — | 1 | 8.89 |
| CHEMBL1088970 | — | — | 1 | 8.64 |
| CHEMBL1092653 | — | — | 1 | 7.35 |
| CHEMBL1088972 | — | — | 1 | 7.10 |
| CHEMBL1092909 | — | — | 1 | 7.05 |
| CHEMBL1089219 | — | — | 1 | 6.75 |
| CHEMBL1092908 | — | — | 1 | 6.75 |
| CHEMBL1092642 | — | — | 1 | 6.72 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 6.68 |
| CHEMBL1088971 | — | — | 1 | 6.26 |
| CHEMBL1088919 | — | — | 1 | 6.17 |
| CHEMBL1088974 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088973 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1088970 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1092653 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1088972 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1092909 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1089219 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1092908 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1092642 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1088971 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1088919 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1088974 | — | IC50 | < | 0.8 | nM | - |