Assay Detail
Binding
CHEMBL1117993
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Displacement of [125H]iodoproxyphan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.13 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082296 | — | — | 1 | 6.92 |
| CHEMBL1086105 | — | — | 1 | 6.42 |
| CHEMBL1083162 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082296 | — | EC50 | = | 119.0 | nM | 6.92 |
| CHEMBL1086105 | — | EC50 | = | 377.0 | nM | 6.42 |
| CHEMBL1083162 | — | EC50 | = | 9000.0 | nM | 5.05 |