Assay Detail
Functional
CHEMBL1118243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily A member 1 (CHEMBL6007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.21 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518292 | ISOVELLERAL | — | 1 | 6.23 |
| CHEMBL1076350 | — | — | 1 | 6.22 |
| CHEMBL29411 | THYMOL | 2.0 | 1 | 5.22 |
| CHEMBL281202 | CARVACROL | 2.0 | 1 | 5.16 |
| CHEMBL1086446 | TOLUENE DIISOCYANATE | — | 1 | 5.00 |
| CHEMBL184238 | URB-597 | 1.0 | 1 | 4.61 |
| CHEMBL258405 | ICILLIN | 3.0 | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518292 | ISOVELLERAL | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1076350 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL29411 | THYMOL | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL281202 | CARVACROL | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1086446 | TOLUENE DIISOCYANATE | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL184238 | URB-597 | EC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL258405 | ICILLIN | EC50 | = | 100000.0 | nM | 4.00 |