Assay Detail
Functional
CHEMBL1119326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.72 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.59 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.54 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 6.51 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.47 |
| CHEMBL830 | EFLORNITHINE | 4.0 | 1 | 4.51 |
| CHEMBL1086194 | — | — | 1 | - |
| CHEMBL1086195 | — | — | 1 | - |
| CHEMBL1086428 | — | — | 1 | - |
| CHEMBL1086429 | — | — | 1 | - |
| CHEMBL1086430 | — | — | 1 | - |
| CHEMBL1086431 | — | — | 1 | - |
| CHEMBL1086432 | — | — | 1 | - |
| CHEMBL1086433 | — | — | 1 | - |
| CHEMBL1086193 | — | — | 1 | - |
| CHEMBL1086435 | — | — | 1 | - |
| CHEMBL1086436 | — | — | 1 | - |
| CHEMBL1086437 | — | — | 1 | - |
| CHEMBL1086438 | — | — | 1 | - |
| CHEMBL1086434 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL265502 | SURAMIN | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL830 | EFLORNITHINE | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL1086194 | — | IC50 | - | — | - | |
| CHEMBL1086195 | — | IC50 | - | — | - | |
| CHEMBL1086428 | — | IC50 | - | — | - | |
| CHEMBL1086429 | — | IC50 | - | — | - | |
| CHEMBL1086430 | — | IC50 | - | — | - | |
| CHEMBL1086431 | — | IC50 | - | — | - | |
| CHEMBL1086432 | — | IC50 | - | — | - | |
| CHEMBL1086433 | — | IC50 | - | — | - | |
| CHEMBL1086193 | — | IC50 | - | — | - | |
| CHEMBL1086435 | — | IC50 | - | — | - | |
| CHEMBL1086436 | — | IC50 | - | — | - | |
| CHEMBL1086437 | — | IC50 | - | — | - | |
| CHEMBL1086438 | — | IC50 | - | — | - | |
| CHEMBL1086434 | — | IC50 | - | — | - |