Assay Detail
Binding
CHEMBL1119418
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Inhibition of human recombinant cathepsin S expressed in Escherichia coli BL21 (DE3) after 10 mins by fluorescence assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 8.18 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1086235 | — | — | 1 | 8.72 |
| CHEMBL1085728 | — | — | 1 | 8.70 |
| CHEMBL1085970 | — | — | 1 | 8.68 |
| CHEMBL1083620 | — | — | 1 | 8.64 |
| CHEMBL1085726 | — | — | 1 | 8.51 |
| CHEMBL1083930 | — | — | 1 | 8.47 |
| CHEMBL1083919 | — | — | 1 | 8.44 |
| CHEMBL1085729 | — | — | 1 | 8.42 |
| CHEMBL1085966 | — | — | 1 | 8.37 |
| CHEMBL1083318 | — | — | 1 | 8.36 |
| CHEMBL347111 | — | — | 1 | 8.26 |
| CHEMBL1085974 | — | — | 1 | 8.25 |
| CHEMBL1085969 | — | — | 1 | 8.24 |
| CHEMBL1085982 | — | — | 1 | 8.24 |
| CHEMBL1085976 | — | — | 1 | 8.23 |
| CHEMBL1085980 | — | — | 1 | 8.21 |
| CHEMBL1085975 | — | — | 1 | 8.21 |
| CHEMBL1085979 | — | — | 1 | 8.21 |
| CHEMBL1085730 | — | — | 1 | 8.18 |
| CHEMBL1085983 | — | — | 1 | 8.15 |
| CHEMBL1083923 | — | — | 1 | 8.14 |
| CHEMBL1085727 | — | — | 1 | 8.10 |
| CHEMBL1085971 | — | — | 1 | 8.06 |
| CHEMBL1085731 | — | — | 1 | 7.99 |
| CHEMBL1085977 | — | — | 1 | 7.94 |
| CHEMBL1085968 | — | — | 1 | 7.80 |
| CHEMBL1085984 | — | — | 1 | 7.64 |
| CHEMBL1085978 | — | — | 1 | 7.62 |
| CHEMBL1085981 | — | — | 1 | 7.37 |
| CHEMBL1085967 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1086235 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1085728 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1085970 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1083620 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1085726 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1083930 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL1083919 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1085729 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1085966 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1083318 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL347111 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL1085974 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL1085969 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1085982 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL1085976 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL1085975 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL1085979 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL1085980 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL1085730 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1085983 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL1083923 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL1085727 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1085971 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL1085731 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL1085977 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL1085968 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL1085984 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL1085978 | — | IC50 | = | 23.8 | nM | 7.62 |
| CHEMBL1085981 | — | IC50 | = | 42.3 | nM | 7.37 |
| CHEMBL1085967 | — | IC50 | = | 49.2 | nM | 7.31 |
| CHEMBL1085973 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL1085972 | — | IC50 | > | 100.0 | nM | - |