Assay Detail
Binding
CHEMBL1119477
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Inhibition of human recombinant Aurora A after 30 mins
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.13 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1083151 | — | — | 1 | 9.40 |
| CHEMBL1083152 | — | — | 1 | 9.00 |
| CHEMBL1086088 | — | — | 1 | 8.52 |
| CHEMBL1085626 | — | — | 1 | 8.40 |
| CHEMBL1084715 | — | — | 1 | 8.30 |
| CHEMBL46817 | — | — | 1 | 8.16 |
| CHEMBL1084969 | — | — | 1 | 8.12 |
| CHEMBL482967 | CYC-116 | 1.0 | 1 | 8.10 |
| CHEMBL1083786 | — | — | 1 | 8.09 |
| CHEMBL1083484 | — | — | 1 | 8.04 |
| CHEMBL1083785 | — | — | 1 | 7.92 |
| CHEMBL1084630 | — | — | 1 | 7.85 |
| CHEMBL1083150 | — | — | 1 | 7.75 |
| CHEMBL1084629 | — | — | 1 | 7.72 |
| CHEMBL1084454 | — | — | 1 | 7.51 |
| CHEMBL298445 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1083151 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL1083152 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1086088 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1085626 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1084715 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL46817 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL1084969 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL482967 | CYC-116 | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL1083786 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL1083484 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL1083785 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1084630 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL1083150 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL1084629 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1084454 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL298445 | — | Ki | = | 73.0 | nM | 7.14 |