Assay Detail
Binding
CHEMBL1119484
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Inhibition of CDK9
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.73 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298445 | — | — | 1 | 8.40 |
| CHEMBL1083152 | — | — | 1 | 8.22 |
| CHEMBL1084715 | — | — | 1 | 8.05 |
| CHEMBL1083151 | — | — | 1 | 7.96 |
| CHEMBL1084969 | — | — | 1 | 6.58 |
| CHEMBL1084454 | — | — | 1 | 6.47 |
| CHEMBL1083150 | — | — | 1 | 6.46 |
| CHEMBL1083785 | — | — | 1 | 6.35 |
| CHEMBL482967 | CYC-116 | 1.0 | 1 | 6.32 |
| CHEMBL1084630 | — | — | 1 | 6.25 |
| CHEMBL1086088 | — | — | 1 | 6.25 |
| CHEMBL46817 | — | — | 1 | 6.24 |
| CHEMBL1083786 | — | — | 1 | 5.94 |
| CHEMBL1083484 | — | — | 1 | 5.83 |
| CHEMBL1084629 | — | — | 1 | 5.58 |
| CHEMBL1085626 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298445 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1083152 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL1084715 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL1083151 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1084969 | — | Ki | = | 264.0 | nM | 6.58 |
| CHEMBL1084454 | — | Ki | = | 337.0 | nM | 6.47 |
| CHEMBL1083150 | — | Ki | = | 348.0 | nM | 6.46 |
| CHEMBL1083785 | — | Ki | = | 448.0 | nM | 6.35 |
| CHEMBL482967 | CYC-116 | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL1084630 | — | Ki | = | 559.0 | nM | 6.25 |
| CHEMBL1086088 | — | Ki | = | 564.0 | nM | 6.25 |
| CHEMBL46817 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL1083786 | — | Ki | = | 1153.0 | nM | 5.94 |
| CHEMBL1083484 | — | Ki | = | 1472.0 | nM | 5.83 |
| CHEMBL1084629 | — | Ki | = | 2605.0 | nM | 5.58 |
| CHEMBL1085626 | — | Ki | > | 10000.0 | nM | - |