Assay Detail
Binding
CHEMBL1119720
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Inhibition of cathepsin K
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Emerging targets in osteoporosis disease modification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.42 | 9.70 |
| Ki | 3 | 9.10 | 10.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203665 | RELACATIB | 2.0 | 1 | 10.39 |
| CHEMBL481611 | ODANACATIB | 3.0 | 1 | 9.70 |
| CHEMBL371064 | BALICATIB | 2.0 | 1 | 8.85 |
| CHEMBL1086008 | — | — | 1 | 8.60 |
| CHEMBL1083675 | — | — | 1 | 8.32 |
| CHEMBL367800 | — | — | 1 | 8.32 |
| CHEMBL450061 | — | — | 1 | 7.75 |
| CHEMBL1085282 | — | — | 1 | 7.46 |
| CHEMBL249966 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203665 | RELACATIB | Ki | = | 0.041 | nM | 10.39 |
| CHEMBL481611 | ODANACATIB | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL371064 | BALICATIB | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1086008 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL1083675 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL367800 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL450061 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1085282 | — | IC50 | = | 34.5 | nM | 7.46 |
| CHEMBL249966 | — | IC50 | < | 1.0 | nM | - |