Assay Detail
Binding
CHEMBL1119824
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](S)-N-(2-(1H-pyrrol-1-yl)phenyl)-1-(2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX2R expressed in CHO cells after 3 hrs by scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 9.22 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1083358 | — | — | 1 | 9.77 |
| CHEMBL1083041 | — | — | 1 | 9.60 |
| CHEMBL1083657 | — | — | 1 | 9.55 |
| CHEMBL1083659 | SUVOREXANT | 4.0 | 1 | 9.46 |
| CHEMBL1083357 | — | — | 1 | 9.44 |
| CHEMBL1084949 | — | — | 1 | 9.33 |
| CHEMBL469146 | — | — | 1 | 9.23 |
| CHEMBL1083658 | — | — | 1 | 8.49 |
| CHEMBL1082414 | — | — | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1083358 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL1083041 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL1083657 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL1083659 | SUVOREXANT | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL1083357 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL1084949 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL469146 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL1083658 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL1082414 | — | Ki | = | 8.5 | nM | 8.07 |