Compound Detail
CHEMBL1082414
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Basic Information
| ChEMBL ID | CHEMBL1082414 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BZCVKCOKZBGXCF-KRWDZBQOSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
413.5
MW (Da)
2.95
ALogP
7
HBA
0
HBD
80.0
PSA (Ų)
0.51
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Orexin receptor type 2 CHEMBL4792 | Ki | 8.07 | 8.07 | 8.5 | 1 |
| Orexin/Hypocretin receptor type 1 CHEMBL5113 | Ki | 7.27 | 7.27 | 54.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Orexin receptor type 2 | Ki | = | 8.5 | nM | 8.07 | Displacement of [3H](S)-N-(2-(1H-pyrrol-1-yl)phenyl)-1-(2-(1-methyl-1H-benzo[d]i... | 20565075 |
| Orexin/Hypocretin receptor type 1 | Ki | = | 54.0 | nM | 7.27 | Displacement of [3H](S)-N-(biphenyl-2-yl)-1-(2-(1-methyl-1H-benzo[d]imidazol-2-y... | 20565075 |
| Orexin/Hypocretin receptor type 1 | Ki | = | 54.0 | nM | 7.27 | Displacement of [3H]N-cyclobutyl-5-methyl-N-(2-(1-methyl-1H-benzo[d]imidazol-2-y... | 20565075 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20565075 | 10.1021/jm100541c | Orexin/Hypocretin receptor type 1 | 2 |
| 20565075 | 10.1021/jm100541c | Orexin receptor type 2 | 1 |
Data from ChEMBL 36 via Core Engine