Assay Detail
Functional
CHEMBL1119865
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Antidyslipidemic activity in human adipocytes assessed as inhibition of isoproteranol-induced production of free fatty acids
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Adipocyte |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.78 | 7.22 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573 | NIACIN | 4.0 | 1 | 7.22 |
| CHEMBL1085289 | 3-(1H-TETRAZOL-5-YL)-4,4A,5,5A-TETRAHYDRO-1H-CYCLOPROPA[4,5]CYCLOPENTA[1,2-C]PYRAZOLE (STRUCTURAL MIX) | — | 2 | 7.05 |
| CHEMBL456145 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573 | NIACIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1085289 | 3-(1H-TETRAZOL-5-YL)-4,4A,5,5A-TETRAHYDRO-1H-CYCLOPROPA[4,5]CYCLOPENTA[1,2-C]PYRAZOLE (STRUCTURAL MIX) | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL456145 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1085289 | 3-(1H-TETRAZOL-5-YL)-4,4A,5,5A-TETRAHYDRO-1H-CYCLOPROPA[4,5]CYCLOPENTA[1,2-C]PYRAZOLE (STRUCTURAL MIX) | Inhibition | - | % | - |