Assay Detail
Functional
CHEMBL1119992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against drug-sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]hypoxanthine assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.40 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082725 | — | — | 1 | 9.70 |
| CHEMBL1082723 | CIPARGAMIN | 2.0 | 1 | 9.05 |
| CHEMBL1084349 | — | — | 1 | 8.52 |
| CHEMBL1086475 | — | — | 1 | 8.40 |
| CHEMBL1083769 | — | — | 1 | 8.05 |
| CHEMBL1083766 | — | — | 1 | 7.70 |
| CHEMBL1083768 | — | — | 1 | 7.57 |
| CHEMBL1082724 | — | — | 1 | 7.11 |
| CHEMBL1086478 | — | — | 1 | 7.08 |
| CHEMBL1083770 | — | — | 1 | 7.08 |
| CHEMBL1085620 | — | — | 1 | 7.07 |
| CHEMBL1085114 | SPIROAZEPINEINDOLE | — | 1 | 7.05 |
| CHEMBL1084948 | — | — | 1 | 6.94 |
| CHEMBL1084077 | — | — | 1 | 6.90 |
| CHEMBL1083219 | — | — | 1 | 6.74 |
| CHEMBL1085371 | — | — | 1 | 6.35 |
| CHEMBL1084078 | — | — | 1 | 6.07 |
| CHEMBL1085370 | — | — | 1 | 5.74 |
| CHEMBL1083767 | — | — | 1 | - |
| CHEMBL1084073 | — | — | 1 | - |
| CHEMBL1085369 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082725 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1082723 | CIPARGAMIN | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1084349 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1086475 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1083769 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1083766 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1083768 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1082724 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1086478 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1083770 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1085620 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1085114 | SPIROAZEPINEINDOLE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1084948 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1084077 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL1083219 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL1085371 | — | IC50 | = | 444.0 | nM | 6.35 |
| CHEMBL1084078 | — | IC50 | = | 857.0 | nM | 6.07 |
| CHEMBL1085370 | — | IC50 | = | 1808.0 | nM | 5.74 |
| CHEMBL1083767 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1084073 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1085369 | — | IC50 | > | 5000.0 | nM | - |